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Positive Samples: Mouse liver
Immunogen sequence: GIADFLSTYQ TKVDKDLQSL EDILHQVENK TSEVKQLIKA IQLTYNPDES SKPNMIDAAT LKSRKMLEEI MKYEASILTH DSSIRYLQEI YNSNNQKIVN LKEKVAQLEA QCQEPCKDTV QIHDITGKDC QDIANKGAKQ SGLYFIKPLK ANQQFLVYCE IDGSGNGWTV FQKRLDGSVD FKKNWIQYKE GFGHLSPTGT TEFWLGNEKI HLISTQSAIP YALRVELEDW NGRTSTADYA MFKVGPEADK YRLTYAYFAG GDAGDAFDGF DFGDDPSDKF F
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: fibg; Fibrinogen gamma chain; fibrinogen gamma-chain; fibrinogen, gamma polypeptide; gamma-fibrinogen; testicular tissue protein Li 70
基因别名: 3010002H13Rik; AI256424; FGG; PRO2061
UniProt ID: (Human) P02679, (Mouse) Q8VCM7
Entrez Gene ID: (Human) 2266, (Mouse) 99571