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Invitrogen
Fibronectin (Radretumab Biosimilar) Recombinant Human Monoclonal Antibody
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Fibronectin (Radretumab Biosimilar) Antibody (MA5-41936) in SDS-PAGE
SDS-PAGE analysis of Fibronectin (Radretumab Biosimilar). Samples were run under reducing (R) and non-reducing (NR) conditions using Fibronectin (Radretumab Biosimilar) monoclonal antibody (Product # MA5-41936). The purity of the protein is greater than 95%.
产品信息
MA5-41936
产品规格
种属反应
Human
宿主/亚型
Human
/ scFv, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human FN EDB
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.46 mg/mL
规格
100 µg
纯化类型
Metal-chelate chromatography
保存液
30mM histidine/PBS, pH 5.8, with 10% sucrose, 0.02% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230-250 kDa. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. Fibronectin is most abundant during embryonic development and tissue remodeling. Fibronectin is also present at high concentrations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins). Fibronectin is present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Fibronectin has been implicated in carcinoma development in lung cancer. Further, Fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents. The gene encoding Fibronectin has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some Fibronectin variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CIG; Cold insoluble globulin (CIG); Cold-insoluble globulin; DKFZp686F10164; DKFZp686H0342; DKFZp686I1370; DKFZp686O13149; epididymis secretory sperm binding protein; extracellular matrix protein; ferritin L subunit; ferritin L-chain; Fibronectin; FN; lnc-ABCA12-8; Migration stimulating factor (MSF); migration-stimulating factor; unnamed protein product
基因别名: CIG; ED-B; FINC; FN; FN1; FNZ; GFND; GFND2; LETS; MSF; SMDCF
UniProt ID: (Human) P02751
Entrez Gene ID: (Human) 2335
angiogenesis
regulation of protein phosphorylation
acute-phase response
cell-substrate junction assembly
cell adhesion
cell-matrix adhesion
calcium-independent cell-matrix adhesion
integrin-mediated signaling pathway
nervous system development
heart development
positive regulation of cell proliferation
regulation of cell shape
response to wounding
positive regulation of gene expression
response to muscle activity
integrin activation
substrate adhesion-dependent cell spreading
endodermal cell differentiation
wound healing
endothelial cell migration
positive regulation of axon extension
positive regulation of fibroblast proliferation
interaction with symbiont
positive regulation of protein kinase B signaling
regulation of ERK1 and ERK2 cascade
negative regulation of transforming growth factor beta production
blood coagulation, fibrin clot formation
negative regulation of monocyte activation
neural crest cell migration involved in autonomic nervous system development
positive regulation of substrate-dependent cell migration, cell attachment to substrate
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