Invitrogen

Filamin A Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Tech Support
Filamin A Polyclonal Antibody

Product Details

PA5-81922

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human FLNA. Recombinant protein control fragment (Product #RP-91889).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2789083

Product Specific Information

Immunogen sequence: IKFADQHVPG SPFSVKVTGE GRVKESITRR RRAPSVANVG SHCDLSLKIP EISIQDMTAQ VTSPSGKTHE AEIVEGENHT YCIRFVPAEM GTHTVSVKYK GQHVPGSPFQ FTV

Highest antigen sequence indentity to the following orthologs: Mouse - 98%, Rat - 99%.

Target Information

Filamin functions as a crosslinking protein forming a flexible link between two actin filaments. It is composed of two identical polypeptide chains each joined to the other at one end, with an actin binding site at the other. It is present in human platelets, lymphocytes, fibroblasts and smooth muscle actin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ABP-280; actin binding protein 280; Actin-binding protein 280; alpha filamin; Alpha-filamin; dilated pupils 2; Endothelial actin-binding protein; Endothelial actin-binding protein 280); filamin 1; filamin A, alpha; filamin, alpha; Filamin-1; Filamin-A; Filamin1; FilaminA; FLN-A; Non-muscle filamin

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Gene Aliases: ABP-280; ABPX; CSBS; CVD1; Dilp2; F730004A14Rik; filamin-1; FLN; FLN-A; FLN1; FLNA; FMD; GENA 379; MNS; NHBP; OPD; OPD1; OPD2; RGD1560614; XLVD; XMVD

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UniProt ID: (Human) P21333

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Entrez Gene ID: (Human) 2316, (Rat) 293860, (Mouse) 192176

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Function(s)
G-protein coupled receptor binding glycoprotein binding signal transducer activity protein binding transcription factor binding Rho GTPase binding Ral GTPase binding kinase binding small GTPase binding mu-type opioid receptor binding Fc-gamma receptor I complex binding protein homodimerization activity poly(A) RNA binding SMAD binding Rac GTPase binding actin filament binding GTPase binding cadherin binding involved in cell-cell adhesion protein kinase C binding protein complex binding actin binding
Process(es)
epithelial to mesenchymal transition adenylate cyclase-inhibiting dopamine receptor signaling pathway biological_process actin cytoskeleton organization actin cytoskeleton reorganization protein localization to cell surface negative regulation of protein catabolic process cilium assembly mRNA transcription from RNA polymerase II promoter positive regulation of transcription factor import into nucleus receptor clustering positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of sequence-specific DNA binding transcription factor activity early endosome to late endosome transport establishment of protein localization protein stabilization cytoplasmic sequestering of protein actin crosslink formation platelet aggregation mitotic spindle assembly negative regulation of transcription from RNA polymerase I promoter cell projection organization negative regulation of apoptotic process positive regulation of substrate adhesion-dependent cell spreading positive regulation of integrin-mediated signaling pathway platelet degranulation platelet activation regulation of cell migration cell junction assembly wound healing, spreading of cells semaphorin-plexin signaling pathway
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