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Invitrogen
Follistatin Polyclonal Antibody
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Product Details
PA5-102666
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human FST(Accession P19883), corresponding to amino acid residues V131-V181.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total FST.
Target Information
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activin-binding protein; Follictatin; Follistatin; follistatin isoform FST317; follistatin-A; FS
Gene Aliases: AL033346; FOL1; FS; FST; Fst-288; RATFOL1
UniProt ID: (Human) P19883, (Rat) P21674, (Mouse) P47931
Entrez Gene ID: (Human) 10468, (Rat) 24373, (Mouse) 14313
negative regulation of transcription from RNA polymerase II promoter
hematopoietic progenitor cell differentiation
signal transduction
negative regulation of activin receptor signaling pathway
positive regulation of hair follicle development
skeletal system development
gamete generation
pattern specification process
female gonad development
BMP signaling pathway
hair follicle morphogenesis
odontogenesis of dentin-containing tooth
keratinocyte proliferation
negative regulation of cell differentiation
negative regulation of follicle-stimulating hormone secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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