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Agrisera
FtsH4/ATP-dependent zinc metalloprotease FtsH4 (mitochondrial) Polyclonal Antibody
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FtsH4/ATP-dependent zinc metalloprotease FtsH4 (mitochondrial) Antibody (AS07-205) in WB
Total protein from Arabidopsis thaliana mitochondria (20 µg) were separated on 10% acrilamide gel and electrophoresis prepared according to Schägger and von Jagov (Anl. Biochem., 1987,166:368-379). After running the gel, proteins were transferred to nitrocellulose membrane using wet transfer (0.22% CAPS, p H 11). Transfer was checked by Ponceau S staining. Blot was destained by several quick washings in dis... View More
产品信息
AS07-205
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated peptide derived from sequence of Arabidopsis thaliana FtsH4.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
规格
200 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 100 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana, Brassica oleracea var. botrytis
靶标信息
FtsH4 encodes a membrane-anchored, ATP-dependent AAA+ metalloprotease that localizes to plant mitochondria as an integral component of the inner mitochondrial membrane, with its proteolytic domain oriented toward the intermembrane space. Structurally, FtsH4 follows the canonical FtsH/i-AAA protease architecture: an N-terminal transmembrane anchor followed by an AAA+ ATPase module that powers substrate unfolding and translocation, and a C-terminal zinc-dependent protease domain (HExxH motif) that mediates processive proteolysis of membrane or membrane-associated protein substrates, thereby supporting mitochondrial protein quality control. Functionally, genetic and physiological studies in Arabidopsis indicate that loss of FtsH4 disrupts mitochondrial homeostasis, correlating with elevated reactive oxygen species and accumulation of oxidatively damaged mitochondrial proteins, and is associated with altered development and stress-linked signaling outputs. FtsH4 deficiency promotes premature leaf senescence and heightened autophagy accompanied by increased salicylic acid accumulation and WRKY-dependent transcriptional changes, supporting a role for this mitochondrial i-AAA protease in maintaining mitochondrial proteostasis while indirectly modulating ROS- and hormone-associated signaling pathways that impact growth and senescence.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AtFTSH4; FTSH protease 4; ftsh4; T19L18.5; T19L18_5
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