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Alomone Labs, LTD
GABA(A) alpha 5 Receptor Polyclonal Antibody
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GABA(A) alpha 5 Receptor Antibody (AGA-025-200UL) in IHC
Expression of GABRA5 in mouse brain - Immunohistochemical staining of mouse hippocampus sections using Anti-GABA (A) alpha 5 Receptor Antibody (#AGA-025), (1;600). A. GABRA5 staining (green).B. Merged image of GABRA5 (green) with nuclei staining using DAPI as the counterstain (blue). GABRA5 is detected in the pyramidal layer (Pyr) (horizontal arrows) and in some interneurons (vertical arrow).
产品信息
AGA-025-200UL
产品规格
种属反应
Rat,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KKERELILNKSTN, corresponding to amino acid residues 364-376 of rat GABRA5, 2ndintracellular loop
偶联物
形式
Lyophilized
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
GABRA5 is a part of GABA, a major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GABA(A) receptor; GABA(A) receptor subunit alpha-5; GABA-A receptor alpha-5 subunit; GABAA receptor alpha5 subunit; GABAAR subunit alpha-5; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, alpha 5; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5; gamma-aminobutyric acid A receptor, alpha 5; Gamma-aminobutyric acid receptor subunit alpha-5; ligand-gated ion channel subunit
基因别名: A230018I05Rik; Gabra-5; Gabra5
UniProt ID: (Rat) P19969, (Mouse) Q8BHJ7
Entrez Gene ID: (Rat) 29707, (Mouse) 110886
behavioral fear response
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
brain development
sensory perception of sound
associative learning
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
neuron development
inner ear receptor cell development
innervation
cochlea development
chloride transmembrane transport
positive regulation of defense response to virus by host
transport
ion transport
chloride transport
signal transduction
mitophagy in response to mitochondrial depolarization
