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GABA(A) alpha 6 Receptor (extracellular) Antibody (AGA-004-200UL) in ICC/IF
Expression of GABRA6 in rat PC12 cells - Cell surface detection of GABRA6 in intact living rat pheochromocytoma (PC12) cells. A. Extracellular staining of cells using Anti-GABA (A) alpha 6 Receptor (extracellular) Antibody (#AGA-004), (1:100), (red). B. Merge of A with the live view of the cell.
产品信息
AGA-004-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
QLEDEGNFYSENVSRILDN(C), corresponding to amino acid residues 20-37 of rat GABRA6, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.7 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A Receptor (GABA-A R) Subtype. GABA-A Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABA-A Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABA-A R function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GABA(A) receptor subunit alpha-6; GABA-A receptor alpha-6 subunit; GABAAR alpha6; GABAAR subunit alpha-6; GABRA 6; gamma-aminobutyric acid; gamma-aminobutyric acid A receptor, alpha 6; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6; gamma-aminobutyric acid A receptor, alpha 6; Gamma-aminobutyric acid receptor subunit alpha-6; subunit alpha 6 gamma-aminobutyric acid (GABA-A) receptor
基因别名: alpha6; GABA-ARalpha6; Gabra-6; Gabra6
UniProt ID: (Mouse) P16305, (Rat) P30191
Entrez Gene ID: (Mouse) 14399, (Rat) 29708
