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Invitrogen
GABRA1/GABRB1/GABRG2 Recombinant Mouse Monoclonal Antibody (1F4)
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产品信息
MA5-51789
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1F4
抗原
This antibody was raised against alpha1β2γ2 GABA-A receptor.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognises alpha 1 Beta 2Gamma2 GABA-A receptor which is found in up to 50% of the synapses in the brain. It's ligand, GABA is a major inhibitory transmitter in the nervous system, binds to this receptor and opens a channel permeable to chloride. Disfunctions of GABAR are found in anxiety, neurodevelopmental disorderds and epilepsy.
靶标信息
These three genes, GABRA1, GABRB1, and GABRG2, play important roles in the formation and functioning of GABA-A receptors, which are critical for maintaining the balance between excitatory and inhibitory signals in the brain. Dysregulation or alterations in these genes can contribute to neurological disorders and impact brain function. Understanding the functions and variations in these genes can provide insights into the underlying mechanisms of these disorders and potentially aid in the development of targeted therapies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GABA(A) receptor subunit alpha-1; GABA(A) receptor subunit beta-1; GABA(A) receptor subunit gamma-2; GABA(A) receptor, alpha 1; GABA(A) receptor, beta 1; GABA(A) receptor, gamma 2; GABAAR subunit alpha-1; GABAAR subunit beta-1; GABAAR subunit gamma-2; gamma-aminobutyric acid (GABA) A receptor, alpha 1; gamma-aminobutyric acid (GABA) A receptor, beta 1; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid A receptor beta 1; Gamma-aminobutyric acid receptor subunit alpha-1; Gamma-aminobutyric acid receptor subunit beta-1; Gamma-aminobutyric acid receptor subunit gamma-2
基因别名: CAE2; ECA2; ECA4; EIEE19; EJM; EJM5; GABRA1; GABRB1; GABRG2; GEFSP3
UniProt ID: (Human) P14867, (Human) P18505, (Human) F5HB82
Entrez Gene ID: (Human) 2554, (Human) 2560, (Human) 2566
GABA-A receptor activity
drug binding
GABA receptor activity
GABA-gated chloride ion channel activity
ligand-gated ion channel activity
GABA receptor binding
extracellular ligand-gated ion channel activity
chloride channel activity
protein binding
benzodiazepine receptor activity
ligand-gated ion channel
transport
gamma-aminobutyric acid signaling pathway
ion transmembrane transport
synaptic transmission, GABAergic
cellular response to histamine
chloride transmembrane transport
ion transport
signal transduction
response to toxic substance
central nervous system neuron development
response to progesterone
ovulation cycle
post-embryonic development
adult behavior
