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Invitrogen
GABRB2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-4727
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Fusion protein from the cytoplasmic loop of the beta 2 subunit of rat GABRB2
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.15 mg/mL
规格
15 µg
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with canine, human, mouse, non-human primate based on 100% sequence homology.
靶标信息
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA R β1-3, GABAA Rγ1-3, GABAA Rδ, GABAA Rε, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GABA(A) receptor subunit beta-2; GABAAR subunit beta-2; GABAARbeta2; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2; gamma-aminobutyric acid A receptor, subunit beta 2; Gamma-aminobutyric acid receptor beta 2; gamma-aminobutyric acid receptor beta-2 subunit; Gamma-aminobutyric acid receptor subunit beta-2; gamma-aminobutyric acid receptor, subunit beta 2; MGC119386; MGC119388; MGC119389
基因别名: AI834970; C030002O17Rik; C030021G16Rik; Gabrab2; Gabrb-2; Gabrb2; GARB2
UniProt ID: (Mouse) P63137, (Rat) P63138
Entrez Gene ID: (Mouse) 14401, (Rat) 25451
transport
ion transport
chloride transport
signal transduction
sensory perception of sound
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
neuron development
synaptic transmission, GABAergic
inner ear receptor cell development
innervation
cellular response to histamine
cochlea development
negative regulation of neuron death
chloride transmembrane transport
gamma-aminobutyric acid signaling pathway
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