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Invitrogen
GAD67 Recombinant Rabbit Monoclonal Antibody (HL1095)
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图: 1 / 8
GAD67 Antibody (MA5-46925) in ICC/IF
Immunofluorescent analysis of GAD67 in DIV9 rat cortical neuron cells. Cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: GAD67 stained by GAD67 monoclonal antibody (Product # MA5-46925) diluted at 1:500. Red: Tau, a Axon marker, stained by Tau antibody [GT287] diluted at 1:500.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-46925
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Cat,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1095
抗原
Recombinant protein encompassing a sequence within the center region of human GAD67. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predominant GAD-67 form and the minor GAD-25 form.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 67 kDa glutamic acid decarboxylase; FLJ45882; GAD 1; GAD 67; GAD-67; Glutamate decarboxylase 1; Glutamate decarboxylase 1 (brain); glutamate decarboxylase 1 variant GAD67NT; Glutamate decarboxylase 67 kDa isoform; GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE); glutamic acid decarboxylase; glutamic acid decarboxylase 1; OTTHUMP00000041055
基因别名: EP10; GAD; Gad-1; GAD1; GAD25; GAD44; GAD67
UniProt ID: (Cat) P14748, (Dog) A0PA85, (Mouse) P48318, (Rat) P18088
Entrez Gene ID: (Cat) 493699, (Dog) 478794, (Mouse) 14415, (Rat) 24379
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
