Invitrogen

GADD34 Polyclonal Antibody

5个已发表图片
9 篇参考文献
查看其他12个GADD34抗体

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说明书
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问题与答案
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说明书
实验方案
问题与答案
技术支持
GADD34 Polyclonal Antibody

产品信息

PA1-139

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
查看6篇已发表文章 6篇已发表文章

免疫细胞化学 (ICC/IF)

1:50-1:100
查看2篇已发表文章 2篇已发表文章

亲和纯化 (AP)

-
查看1篇已发表文章 1篇已发表文章
产品规格

种属反应

Human, Mouse

已发表种属

C. elegans, Human, Mouse, Non-human primate

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to amino acids C R(595) I T Q A Q E E L S P C L T P A A R(612) from human GADD34
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2539894

产品详细信息

Western blot analysis of PA1-139 detects an ~73 kDa protein in HeLa cells. PA1-139 shows specificity to GADD34 and can be blocked by incubating with an abundance of the immunizing peptide.

靶标信息

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Growth arrest and DNA damage-inducible protein GADD34; growth arrest and DNA-damage-inducible 34; myeloid differentiation primary response gene 116; Myeloid differentiation primary response protein MyD116; Myeloid differentiation primary response protein MyD116 homolog; PR15A; Protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A; protein phosphatase 1, regulatory subunit 15A

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基因别名: 9630030H21; GADD34; Myd116; PPP1R15A

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UniProt ID: (Human) O75807, (Mouse) P17564

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Entrez Gene ID: (Human) 23645, (Mouse) 17872

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功能
protein binding protein phosphatase 1 binding protein phosphatase type 1 regulator activity protein kinase binding protein phosphatase type 1 activator activity protein phosphatase regulator activity protein phosphatase binding
参与通路
regulation of translation apoptotic process positive regulation of gene expression endoplasmic reticulum unfolded protein response negative regulation of phosphoprotein phosphatase activity positive regulation of phosphoprotein phosphatase activity positive regulation of peptidyl-serine phosphorylation response to endoplasmic reticulum stress negative regulation of protein dephosphorylation regulation of translational initiation by eIF2 alpha dephosphorylation positive regulation of transcription from RNA polymerase I promoter regulation of catalytic activity regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation peptidyl-serine dephosphorylation protein localization to endoplasmic reticulum positive regulation of peptidyl-serine dephosphorylation negative regulation of response to endoplasmic reticulum stress negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress positive regulation of protein phosphorylation cellular response to DNA damage stimulus cell cycle arrest aging negative regulation of cell proliferation negative regulation of peptidyl-threonine phosphorylation negative regulation of protein processing positive regulation of translational initiation in response to stress cellular response to UV cellular response to drug response to immobilization stress response to cocaine positive regulation of apoptotic process regulation of angiogenesis negative regulation of cell death intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to antibiotic cellular response to carbohydrate stimulus cellular response to methyl methanesulfonate cellular response to calcium ion starvation response to environmental enrichment cellular response to oxygen-glucose deprivation negative regulation of PERK-mediated unfolded protein response positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation cellular response to desipramine cellular response to cordycepin cellular response to gold(3+) cellular response to methamphetamine hydrochloride
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