Invitrogen

GADD34 Polyclonal Antibody

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3 篇参考文献
查看其他12个GADD34抗体

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

PA5-30486

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
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亲和纯化 (AP)

-
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产品规格

种属反应

Human

已发表种属

C. elegans, Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of human GADD34. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 1% BSA, 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2547960

产品详细信息

Recommended positive controls: 293T, A431, Jurkat, Raji.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Growth arrest and DNA damage-inducible protein GADD34; growth arrest and DNA-damage-inducible 34; Myeloid differentiation primary response protein MyD116 homolog; PR15A; Protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A; protein phosphatase 1, regulatory subunit 15A

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基因别名: GADD34; PPP1R15A

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UniProt ID: (Human) O75807

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Entrez Gene ID: (Human) 23645

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功能
protein binding protein phosphatase 1 binding protein phosphatase type 1 regulator activity protein kinase binding protein phosphatase type 1 activator activity
参与通路
positive regulation of protein phosphorylation apoptotic process cellular response to DNA damage stimulus cell cycle arrest aging negative regulation of cell proliferation negative regulation of peptidyl-threonine phosphorylation negative regulation of protein processing endoplasmic reticulum unfolded protein response positive regulation of translational initiation in response to stress negative regulation of phosphoprotein phosphatase activity positive regulation of phosphoprotein phosphatase activity cellular response to UV response to endoplasmic reticulum stress negative regulation of protein dephosphorylation cellular response to drug response to immobilization stress regulation of translational initiation by eIF2 alpha dephosphorylation response to cocaine positive regulation of apoptotic process regulation of angiogenesis negative regulation of cell death regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress peptidyl-serine dephosphorylation protein localization to endoplasmic reticulum cellular response to antibiotic cellular response to carbohydrate stimulus cellular response to methyl methanesulfonate cellular response to calcium ion starvation response to environmental enrichment cellular response to oxygen-glucose deprivation positive regulation of peptidyl-serine dephosphorylation negative regulation of PERK-mediated unfolded protein response negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation cellular response to desipramine cellular response to cordycepin cellular response to gold(3+) cellular response to methamphetamine hydrochloride negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
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