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Invitrogen
GALR1 Recombinant Rabbit Monoclonal Antibody (A1)
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图: 1 / 8
GALR1 Antibody (760002R) in ICC/IF
Immunofluorescence analysis of GALR1 was performed using GALR1 Recombinant Rabbit Monoclonal Antibody (A1) (Product # 760002R) in LNCaP cells. The cells were fixed with 4% paraformaldehyde for 10 min, permeabilized with 0.1% Triton™ X-100 for 15 min and blocked with 2% BSA for 1 hr at RT. The cells were labeled with GALR1 Recombinant Rabbit Monoclonal Antibody (A1) (Product # 760002R, 1:100) in 0.1% BSA, incubated at 4°C overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ Plus... View More
产品信息
760002R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
A1
抗原
Peptides corresponding to human GALR1 [1) aa329-aa349 2) aa14-aa32]
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
Recombinant Rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
靶标信息
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G-protein coupled receptor; GALR1; Gal receptor 1; Gal-1 receptor; Gal-r1; GAL1-R; Galanin r1 receptor; Galanin receptor type 1; Galanin-1 receptor; Galn1r; GALR-1; Hugal 1-r
基因别名: GALNR; GALNR1; GALR1
UniProt ID: (Human) P47211, (Mouse) P56479, (Rat) Q62805
Entrez Gene ID: (Human) 2587, (Mouse) 14427, (Rat) 50577
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of cortisol secretion
chemical synaptic transmission
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