Invitrogen

GAS6 Polyclonal Antibody

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View all (11) GAS6 antibodies

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Datasheet
Protocols
Questions & Answers
Tech Support
GAS6 Polyclonal Antibody

Product Details

PA5-79300

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

2-5 µg/mL
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human GAS 6 recombinant protein (Position: M488-S660).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746416

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: rat brain tissue, mouse brain tissue. IHC: mouse spleen tissue, rat spleen tissue. ICC/IF: A431 cell. Flow: THP-1 cell.

Target Information

This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: AXL receptor tyrosine kinase ligand; AXL stimulatory factor; GAS 6; GAS-6; GPF; growth arrest-specific 6; Growth arrest-specific protein 6; growth-potentiating factor

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Gene Aliases: AXLLG; AXSF; Gas-6; GAS6

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UniProt ID: (Human) Q14393, (Mouse) Q61592

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Entrez Gene ID: (Human) 2621, (Rat) 58935, (Mouse) 14456

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Function(s)
phosphatidylserine binding receptor binding voltage-gated calcium channel activity calcium ion binding protein binding protein tyrosine kinase activator activity receptor tyrosine kinase binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process receptor agonist activity binding, bridging growth factor activity metal ion binding extracellular matrix protein
Process(es)
neuron migration positive regulation of protein phosphorylation positive regulation of cytokine-mediated signaling pathway platelet degranulation positive regulation of glomerular filtration signal peptide processing protein phosphorylation ER to Golgi vesicle-mediated transport phagocytosis apoptotic process cell cycle arrest cell adhesion signal transduction enzyme linked receptor protein signaling pathway cell proliferation cellular response to starvation positive regulation of gene expression negative regulation of tumor necrosis factor-mediated signaling pathway macrophage cytokine production cell migration peptidyl-serine phosphorylation fusion of virus membrane with host plasma membrane viral genome replication platelet activation organ regeneration cell-substrate adhesion positive regulation of TOR signaling activation of protein kinase B activity negative regulation of interferon-gamma production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of natural killer cell differentiation positive regulation of peptidyl-serine phosphorylation negative regulation of protein import into nucleus, translocation cellular response to interferon-alpha cellular response to drug B cell chemotaxis regulation of growth negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process apoptotic cell clearance negative regulation of sequence-specific DNA binding transcription factor activity protein kinase B signaling positive regulation of protein kinase activity negative regulation of transcription, DNA-templated viral entry into host cell receptor-mediated virion attachment to host cell positive regulation of protein export from nucleus positive regulation of fibroblast proliferation negative regulation of interleukin-1 secretion positive regulation of phagocytosis leukocyte migration positive regulation of protein kinase B signaling positive regulation of protein tyrosine kinase activity negative regulation of biomineral tissue development positive regulation of ERK1 and ERK2 cascade platelet aggregation calcium ion transmembrane transport cellular response to vitamin K cellular response to glucose stimulus cellular response to growth factor stimulus protein targeting to plasma membrane extracellular matrix assembly dendritic cell differentiation hematopoietic stem cell migration to bone marrow negative regulation of oligodendrocyte apoptotic process negative regulation of interleukin-6 secretion negative regulation of fibroblast apoptotic process negative regulation of endothelial cell apoptotic process positive regulation of dendritic cell chemotaxis negative regulation of renal albumin absorption negative regulation of dendritic cell apoptotic process blood coagulation tissue regeneration tissue remodeling positive regulation of receptor activity regulation of ion transmembrane transport
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