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Invitrogen
GASP2 Monoclonal Antibody (289827)
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产品信息
MA5-61106
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
289827
抗原
Mouse myeloma cell line NS0-derived recombinant human GASP-2/WFIKKN, Ala20-Asp548
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
The GASP2 gene encodes for a protein known as G protein-coupled receptor-associated sorting protein 2. GASP2 is involved in the regulation of G protein-coupled receptors (GPCRs), which are crucial for transmitting signals from the external environment to the inside of a cell. This protein plays a key role in the intracellular trafficking and sorting of GPCRs, affecting their recycling and degradation pathways, which are critical for receptor resensitization and downregulation. GASP2 assists in marking GPCRs for degradation post endocytosis, thereby influencing receptor availability on the cell surface and modulating cellular responsiveness to ligands. Dysregulation of GASP2 expression or function can impact GPCR signaling pathways, potentially affecting various physiological processes and contributing to disease states where GPCR signaling is altered, such as in certain neurological disorders and cancers. The role of GASP2 in GPCR regulation makes it a point of interest for therapeutic targeting to modulate GPCR-related signaling pathways for clinical benefits in diverse diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GASP-2; Growth and differentiation factor-associated serum protein 2; hGASP-2; WAP four-disulfide core domain 20A; WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein; WAP, FS, Ig, KU, and NTR-containing protein; WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
基因别名: C16orf12; GASP2; PSEC0040; RJD2; WFDC20A; WFIKKN; WFIKKN1
UniProt ID: (Human) Q96NZ8
Entrez Gene ID: (Human) 117166
