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Abnova
GATA2 Polyclonal Antibody, MaxPab™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00002624-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GATA2 (NP_116027.2, 1 a.a. approximately 480 a.a) full-length human protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHNPWTVSP FSKTPLHPSA AGGPGGPLSV YPGAGGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG SAARGEDKDG VKYQVSLTES MKMESGSPLR PGLATMGTQP ATHHPIPTYP SYVPAAAHDY SSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SNKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG
靶标信息
GATA2 (GATA binding protein 2) belongs to the GATA family of transcription factors. GATA proteins play a very important role in signaling pathways controlling proliferation and differentiation of erythroid progenitor cells. There are 6 transcription factors in the GATA family: GATA1 to GATA6. GATA2 is a transcriptional activator regulating endothelin-1 gene expression in endothelial cells. It also appears to be involved in differentiation of other tissue types (uro-genital and nervous) during embryogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ45948; MGC2306; unnamed protein product
基因别名: DCML; Gata-2; IMD21; MONOMAC; NFE1B
UniProt ID: (Human) P23769, (Mouse) O09100
Entrez Gene ID: (Human) 2624, (Mouse) 14461
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcription coactivator binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
C2H2 zinc finger domain binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
neuron migration
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of cytosolic calcium ion concentration
anatomical structure morphogenesis
positive regulation of gene expression
negative regulation of gene expression
cell differentiation
response to lipid
eosinophil fate commitment
positive regulation of mast cell degranulation
positive regulation of blood vessel endothelial cell migration
cell fate commitment
fat cell differentiation
positive regulation of neuron differentiation
negative regulation of Notch signaling pathway
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
system development
positive regulation of phagocytosis
regulation of developmental process
positive regulation of phagocytosis, engulfment
vascular wound healing
positive regulation of cell migration involved in sprouting angiogenesis
cochlea development
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
negative regulation of neural precursor cell proliferation
negative regulation of endothelial cell apoptotic process
urogenital system development
cell fate determination
embryonic placenta development
regulation of primitive erythrocyte differentiation
ventral spinal cord interneuron differentiation
cell differentiation in hindbrain
commitment of neuronal cell to specific neuron type in forebrain
central nervous system neuron development
pituitary gland development
neuron differentiation
somatic stem cell population maintenance
inner ear morphogenesis
negative regulation of fat cell differentiation
negative regulation of myeloid cell differentiation
positive regulation of erythrocyte differentiation
negative regulation of macrophage differentiation
positive regulation of megakaryocyte differentiation
cell maturation
animal organ development
neuron fate commitment
homeostasis of number of cells within a tissue
regulation of multicellular organismal process
definitive hemopoiesis
semicircular canal development
GABAergic neuron differentiation
regulation of forebrain neuron differentiation
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