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Invitrogen
GATAD2A Recombinant Rabbit Monoclonal Antibody (JE55-37)
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GATAD2A Antibody (MA5-42506) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded human stomach carcinoma tissue using GATAD2A Recombinant Monoclonal Antibody (Product # MA5-42506). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the GATAD2A... View More
产品信息
MA5-42506
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JE55-37
抗原
Synthetic peptide within N-terminal Human GATAD2A
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Control: MCF-7 cell lysates, human tonsil tissue, human thyroid tissue, human colon carcinoma tissue, human skin tissue, human breast carcinoma tissue, human esophagus tissue, human stomach carcinoma tissue, human small intestine tissue, mouse testis tissue, mouse stomach tissue, Daudi.
靶标信息
GATAD2A is a gene encoding a protein that functions as a subunit of the nucleosome remodeling and deacetylase (NuRD) complex, which plays a crucial role in chromatin remodeling and gene expression regulation. Located on the human chromosome, GATAD2A contains proline-rich PPPL theta motifs that facilitate interactions with MYND domains in proteins such as ZMYND8, distinguishing it from its paralog GATAD2B. This gene is important for various cellular processes, particularly during neural development, where it participates in modulating chromatin structure through histone deacetylation and ATP-dependent remodelings, like those mediated by NuRD. Moreover, GATAD2A has been implicated in certain neurodevelopmental disorders, suggesting its distinct functional roles in cellular contexts. Additionally, research has identified circular RNA variants of GATAD2A, which have been shown to influence viral replication, indicating its broader impact on cellular function beyond chromatin modification.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GATA zinc finger domain-containing protein 2A; Hp66alpha; MGC29315; MGC36975; p66a; Transcriptional repressor p66 alpha; Transcriptional repressor p66-alpha
基因别名: 1110066C11Rik; BC031407; C80248; GATAD2A; p66alpha
UniProt ID: (Human) Q86YP4, (Mouse) Q8CHY6
Entrez Gene ID: (Human) 54815, (Mouse) 234366
negative regulation of transcription from RNA polymerase II promoter
DNA methylation
transcription, DNA-templated
negative regulation of transcription, DNA-templated
blood vessel development
in utero embryonic development
neural fold formation
regulation of transcription, DNA-templated
embryonic body morphogenesis
programmed cell death
anterior neuropore closure
