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Invitrogen
GATSL3 Polyclonal Antibody
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产品信息
PA5-139983
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: EQDLSVVIHT LAQEFDIYRE VGGEPVPVTR DDSSNGFPRT QHGPSPTVHP IQSPQNRFCV LTLDPET
Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 94%.
靶标信息
GATSL3 functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cellular arginine sensor for mTORC1 protein 1; Cytosolic arginine sensor for mTORC1 subunit 1; GATS protein-like 3; GATS-like protein 3
基因别名: CASTOR1; GATSL3
UniProt ID: (Human) Q8WTX7
Entrez Gene ID: (Human) 652968
