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Invitrogen
GBA Polyclonal Antibody
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GBA Antibody (PA5-120497) in WB
Western blot analysis of GBA in extracts of various cell lines. Samples were incubated with GBA Polyclonal antibody (Product # PA5-120497) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-120497
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Protein (or fragment)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.05 mg/mL
规格
105 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: MCF7, SKOV3, NCI-H460. The target is usually found in the following locations: Lumenal side, Lysosome membrane, Peripheral membrane protein.
Immunogen sequence: ARPCIPKSFG YSSVVCVCNA TYCDSFDPPT FPALGTFSRY ESTRSGRRME LSMGPIQANH TGTGLLLTLQ PEQKFQKVKG FGGAMTDAAA LNILALSPPA QNLLLKSYFS EEGIGYNIIR VPMASCDFSI RTYTYADTPD DFQLHNFSLP EEDTKLKIPL IHRALQLAQR PVSLLASPWT SPTWLKTNGA VNGKGSLKGQ PGDIYHQTWA R
靶标信息
GBA encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acid beta-glucosidase; alglucerase; beta-GC; beta-glucocerebrosidase; beta-glucosylceramidase 1; cholesterol glucosyltransferase; cholesteryl-beta-glucosidase; D-glucosyl-N-acylsphingosine glucohydrolase; glucocerebrosidase; glucocerebrosidase precursor (5' end put.); putative; glucosidase, beta, acid; glucosylceramidase-like protein; imiglucerase; lysosomal acid GCase; lysosomal cholesterol glycosyltransferase; lysosomal galactosylceramidase; lysosomal glucocerebrosidase; lysosomal glycosylceramidase; SGTase; unnamed protein product
基因别名: GBA; GCB; GLUC
UniProt ID: (Human) P04062
Entrez Gene ID: (Human) 2629, (Rat) 684536
mitophagy
sphingolipid metabolic process
glucosylceramide metabolic process
glucosylceramide catabolic process
autophagy
mitochondrion organization
lysosome organization
central nervous system development
cholesterol metabolic process
determination of adult lifespan
glycolipid biosynthetic process
cellular response to starvation
response to pH
microglia differentiation
regulation of macroautophagy
antigen processing and presentation
lipid storage
cerebellar Purkinje cell layer formation
pyramidal neuron differentiation
respiratory electron transport chain
termination of signal transduction
protein catabolic process
neuron projection development
negative regulation of protein complex assembly
regulation of TOR signaling
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of interleukin-6 production
T cell differentiation in thymus
response to testosterone
regulation of protein catabolic process
regulation of membrane potential
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of MAPK cascade
negative regulation of neuron apoptotic process
response to estrogen
sphingosine biosynthetic process
ceramide biosynthetic process
cell maturation
brain morphogenesis
homeostasis of number of cells
negative regulation of inflammatory response
neurological system process
neuromuscular process
regulation of protein metabolic process
negative regulation of protein metabolic process
neuron apoptotic process
establishment of skin barrier
microglial cell proliferation
motor behavior
cellular response to tumor necrosis factor
hematopoietic stem cell proliferation
response to dexamethasone
lymphocyte migration
response to thyroid hormone
skin epidermis development
beta-glucoside catabolic process
positive regulation of neuronal action potential
autophagosome organization
positive regulation of type 2 mitophagy
lysosomal protein catabolic process
glycolipid catabolic process
regulation of lysosomal protein catabolic process
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