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Invitrogen
GCKR Polyclonal Antibody
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GCKR Antibody (PA5-109758) in WB
Western blot analysis of GCKR in extracts of various cell lines. Samples were incubated with GCKR Polyclonal antibody (Product # PA5-109758) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-109758
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GCKR (NP_001477.2).
偶联物
形式
Liquid
浓度
0.11 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MPGTKRFQHV IETPEPGKWE LSGYEAAVPI TEKSNPLTQD LDKADAENIV RLLGQCDAEI FQEEGQALST YQRLYSESIL TTMVQVAGKV QEVLKEPDGG LVVLSGGGTS GRMAFLMSVS FNQLMKGLGQ KPLYTYLIAG GDRSVVASRE GTEDSALHGI EELKKVAAGK KRVIVIGISV GLSAPFVAGQ MDCCMNNTAV FLPVLVGFNP VSMARNDPIE DWSSTFRQVA ERMQKMQEKQ KAFVLNPAIG PEGLSGSSRM KGGSATKILL ETLLLAAHKT VDQGIAASQR CLLEILRTFE
靶标信息
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GKRP; Glucokinase regulator; Glucokinase regulatory protein; hexokinase 4
基因别名: FGQTL5; GCKR; GKRP; GLRE
UniProt ID: (Human) Q14397, (Rat) Q07071, (Mouse) Q91X44
Entrez Gene ID: (Human) 2646, (Rat) 25658, (Mouse) 231103
protein import into nucleus, translocation
carbohydrate metabolic process
response to fructose
regulation of glucose transport
negative regulation of glucokinase activity
urate metabolic process
triglyceride homeostasis
cellular glucose homeostasis
glucose metabolic process
positive regulation of glucokinase activity
protein localization to nucleus
negative regulation of catalytic activity
detection of glucose
