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Bethyl Laboratories
GCN1L1 Polyclonal Antibody
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GCN1L1 Antibody (A301-843A) in WB
Detection of human GCN1L1 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, Jurkat, RPMI-8226, and Hep-G2 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-GCN1L1 antibody (Product # A301-843A) (lot A301-843A-3) used for WB at 0.04 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
产品信息
A301-843A
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 2621 and 2671 of human general control of amino-acid synthesis 1-like 1.
偶联物
形式
Liquid
浓度
0.20 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GCN1 (general control of amino-acid synthesis 1, yeast)-like 1; GCN1 eIF-2-alpha kinase activator homolog; GCN1 eIF2 alpha kinase activator homolog; GCN1 general control of amino-acid synthesis 1-like 1; GCN1-like protein 1; General control of amino-acid synthesis 1-like protein 1; HsGCN1; peroxisome proliferator activated receptor interacting complex protein; Stalled ribosome sensor GCN1; Translational activator GCN1
基因别名: 4932409G22; AL022764; G431004K08Rik; GCN1; GCN1L; GCN1L1; KIAA0219; mKIAA0219; PRIC295
UniProt ID: (Human) A8KAY1, (Mouse) E9PVA8
Entrez Gene ID: (Human) 10985, (Mouse) 231659, (Rat) 690632
translation
regulation of translation
positive regulation of kinase activity
cellular response to amino acid starvation
positive regulation of transcription from RNA polymerase II promoter in response to stress
regulation of protein kinase activity
cell-cell adhesion
cellular response to leucine starvation
biological_process
