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Fabgennix
GCN2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
GCN2-201Y
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Chicken
/ IgY
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 1600-1700 on human GCN2 protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
EIF2AK4 (GCN2) is a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor-2 in response to low amino acid availability. It plays a role as an activator of the integrated stress response required for adapatation to amino acid starvation. Mutations in the gene lead to pulmonary vennocclusive disease 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: eIF-2-alpha kinase GCN2; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2 eIF2alpha kinase; GCN2-like protein; mGCN2
Gene Aliases: 2610011M03; EIF2AK4; GCN2; KIAA1338; MGCN2
UniProt ID: (Mouse) Q9QZ05
Entrez Gene ID: (Mouse) 27103, (Rat) 114859
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
eukaryotic translation initiation factor 2alpha kinase activity
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
eukaryotic initiation factor eIF2 binding
aminoacyl-tRNA synthetase
non-receptor serine/threonine protein kinase
translational protein
regulation of translational initiation
protein phosphorylation
cellular response to starvation
positive regulation of gene expression
regulation of translational initiation by eIF2 alpha phosphorylation
phosphorylation
negative regulation of translation
endoplasmic reticulum unfolded protein response
cellular response to amino acid starvation
response to endoplasmic reticulum stress
regulation of translational initiation in response to stress
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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