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Abnova
GIMAP8 Polyclonal Antibody, MaxPab™
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产品信息
H00155038-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GIMAP8 (NP_783161, 1 a.a. approximately 665 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSEQSCQMSE LRLLLLGKCR SGKSATGNAI LGKHVFKSKF SDQTVIKMCQ RESWVLRERK VVVIDTPDLF SSIACAEDKQ RNIQHCLELS APSLHALLLV IAIGHFTRED EETAKGIQQV FGAEARRHII IVFTRKDDLG DDLLQDFIEK NKPLKQLVQD YEGRYCIFNN KTNSKDEQIT QVLELLRKVE SLVNTNGGPY HVNFKTEGSR FQDCVNEAAS QEGDKPQGPR ERQLQSTGPE QNPGTSELTV LLVGKRGAGK SAAGNSILGR QAFQTGFSEQ SVTQSFLSES RSWRKKKVSI IDAPDISSLK NIDSEVRKHI CTGPHAFLLV TPLGFYTKND EAVLSTIQNN FGEKFFEYMI ILLTRKEDLG DQDLDTFLRN SNKALYGLIQ KCKNRYSAFN YRATGEEEQR QADELLEKIE SMVHQNGNKH CVFREKETLN IVLVGRSGTG KSATGNSILG SLVFTSRLRA QPVTKTSQSG RRTWDGQEVV VVDTPSFNQM LDVEKDPSRL EEEVKRCLSC CEKGDTFFVL VFQLGRFTEE DKTAVAKLEA IFGADFTKYA IMLFTRKEDL GAGNLEDFMK NSDNKALRRI FKKCGRRVCA FNNKETGQAQ ETQVKALLTK VNDLRKESGW SGYPHTQENV SKLIKNVQEM SQAEKLLKNL IGILQ
靶标信息
The GIMAP8 gene, part of the GTPase of the Immunity-Associated Proteins (GIMAP) family, is located on chromosome 7q36.1. This gene encodes a protein that is predominantly expressed in immune cells, including T and B lymphocytes. GIMAP8 is involved in the regulation of lymphocyte survival and development, particularly during the early and late stages of T cell development in the thymus, as well as during B cell maturation. Studies have shown that GIMAP8 expression levels are significantly altered in various cancers, including breast and lung adenocarcinoma, where its upregulation in tumor tissues correlates with improved overall survival in specific cancer subtypes. This suggests a potential role for GIMAP8 in tumor immune surveillance and as a prognostic biomarker. Additionally, GIMAP8's functions appear essential but redundant enough that mouse models deficient in this gene do not exhibit major defects in T or B cell development, indicating compensation by other family members.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GTPase IMAP family member 8; hIAN6; human immune associated nucleotide 6; IAN-9; Immune-associated nucleotide-binding protein 9; Protein IanT
基因别名: GIMAP8; IAN-9; IAN6; IAN9; IANT
UniProt ID: (Human) Q8ND71
Entrez Gene ID: (Human) 155038
