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Invitrogen
GIMAP8 Polyclonal Antibody
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产品信息
PA5-53641
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SWVLRERKVV VIDTPDLFSS IACAEDKQRN IQHCLELSAP SLHALLLVIA IGHFTREDEE TAKGIQQVFG AEARRHIIIV FTRKDDLGDD LLQDFIEKNK PLKQLVQDYE GRYCIFNNKT NSKDEQITQV LELLRKVESL VNT
Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 48%.
靶标信息
The GIMAP8 gene, part of the GTPase of the Immunity-Associated Proteins (GIMAP) family, is located on chromosome 7q36.1. This gene encodes a protein that is predominantly expressed in immune cells, including T and B lymphocytes. GIMAP8 is involved in the regulation of lymphocyte survival and development, particularly during the early and late stages of T cell development in the thymus, as well as during B cell maturation. Studies have shown that GIMAP8 expression levels are significantly altered in various cancers, including breast and lung adenocarcinoma, where its upregulation in tumor tissues correlates with improved overall survival in specific cancer subtypes. This suggests a potential role for GIMAP8 in tumor immune surveillance and as a prognostic biomarker. Additionally, GIMAP8's functions appear essential but redundant enough that mouse models deficient in this gene do not exhibit major defects in T or B cell development, indicating compensation by other family members.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GTPase IMAP family member 8; hIAN6; human immune associated nucleotide 6; IAN-9; Immune-associated nucleotide-binding protein 9; Protein IanT
基因别名: GIMAP8; IAN-9; IAN6; IAN9; IANT
UniProt ID: (Human) Q8ND71
Entrez Gene ID: (Human) 155038
