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Invitrogen
GKN1 Monoclonal Antibody (759821)
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GKN1 Antibody (MA5-24367) in IHC (F)
Immunohistochemical analysis of GKN1 in perfusion fixed frozen sections of mouse intestine. Samples were incubated with GKN1 monoclonal antibody (Product # MA5-24367) using a dilution of 25 µg/mL overnight at 4 °C followed by NorthernLights™ 557-conjugated Anti-Rat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to gastric glands.
产品信息
MA5-24367
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
759821
抗原
E. coli-derived recombinant mouse Gastrokine 1 Tyr38-Tyr201
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody detects mouse Gastrokine 1 in direct ELISAs and mouse and rat Gastrokine 1 in Western blots. In Western blots, approximately 10% cross-reactivity with recombinant human (rh) Gastrokine 1 and no cross-reactivity with rhBlottin is observed.
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
靶标信息
Gastrokine 1, also known as GKN1 and CA11, is a 185 amino acid containing secreted protein belonging to the gastrokine family with a BRICHOS domain and an asn-rich region. GKN1 (also known as an antioncogene) is reported to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. Differential display of normal and cancerous gastric tissue suggested that this protein is predominantly expressed in stomach and the expression is down-regulated to considerable frequency in cancer tissue or gastric cancer cell lines examined. This extra cellular protein is co-secreted with mucins and is a signaling growth factor with mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 18 kDa antrum mucosa protein; AMP-18; foveolin; Gastrokine-1; Protein CA11 homolog
基因别名: 2200002K21Rik; AMP-18; Amp18; BRICD1; Ca11; Fov; Gkn1
UniProt ID: (Mouse) Q9CR36
Entrez Gene ID: (Mouse) 66283
