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Positive test controls include: 293T, MCF7, HeLa, NIH/3T3. The target is usually found in the following locations: Cytoplasm, Nucleus.
Gli-2 belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: GLI family zinc finger protein 2; GLI-Kruppel family member GLI2; glioma-associated oncogene family zinc finger 2; oncogene GLI2; Tax helper protein; tax helper protein 1; tax helper protein 2; tax-responsive element-2 holding protein; tax-responsive element-25-bp sequence binding protein; Zinc finger protein GLI2
基因别名: AW546128; CJS; GLI2; HPE9; PHS2; THP; THP1; THP2
UniProt ID: (Human) Q15591, (Mouse) Q0VGT2
Entrez Gene ID: (Human) 2736, (Rat) 304729, (Mouse) 14633