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Invitrogen
GLT-1 Polyclonal Antibody
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GLT-1 Antibody (PA5-19706) in WB
Western blot was performed using Anti-GLT-1 Polyclonal Antibody (Product # PA5-19706) and a 55 kDa band corresponding to GLT-1 was observed in Mouse Brain, Rat Brain and Mouse Cerebellum when compared to other tissue extracts tested which are reported to be low. Tissue extracts (30 µg lysate) of Mouse Kidney (Lane 1), Mouse Lung (Lane 2), Rat Kidney (Lane 3), Rat Lung (Lane 4), Mouse Brain (Lane 5), Rat Brain (Lane 6) and Mouse Cerebellum (Lane 7) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved... View More
产品信息
PA5-19706
产品规格
种属反应
Mouse,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide conjugated to KLH derived from within residues 550 to the C-terminus of Rat Glutamate Transporter 1 (EAAT2).
偶联物
形式
Liquid
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with human based on sequence homology.
靶标信息
Excitatory amino acid transporter 2 (EAAT2) is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis (ALS.) Alternatively spliced transcript variants of this gene have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: EAAT2 variant mEAAT2/5UT5; Excitatory amino acid transporter 2; glial high affinity glutamate transporter; GLT-1; GLT1a; GLT1b; GLT1c; GLUT-R; glutamate transporter 1c; high affinity glucose transporter; OTTHUMP00000165209; OTTHUMP00000165210; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2; solute carrier family 1, member 2
基因别名: 1700091C19Rik; 2900019G14Rik; AI159670; Eaat2; Glt; GLT-1; GLT1; MGLT1; Slc1a2
UniProt ID: (Mouse) P43006, (Rat) P31596
Entrez Gene ID: (Mouse) 20511, (Rat) 29482
transport
dicarboxylic acid transport
nervous system development
visual behavior
response to light stimulus
response to wounding
multicellular organism aging
L-glutamate transport
telencephalon development
adult behavior
cellular response to extracellular stimulus
multicellular organism growth
sodium ion transmembrane transport
response to drug
response to amino acid
positive regulation of glucose import
L-glutamate import
D-aspartate import
L-glutamate transmembrane transport
neurotransmitter transport
