Invitrogen

GLUT1 Polyclonal Antibody

Name: GLUT1 Polyclonal Antibody
Brand: Invitrogen
SKU: PA1-1063

2个已发表图片

6 篇参考文献

查看其他28个GLUT1抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)
已发表图片 (2)

GLUT1 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 5

GLUT1 Antibody (PA1-1063) in ICC/IF

Immunofluorescent analysis of Glucose Transporter 1 using anti-Glucose Transporter 1 polyclonal antibody (Product # PA1-1063) shows staining in HMVEC Cells.

Product Image Gallery

Immunogen image

Immunogen Image GLUT1 Polyclonal Antibody

产品信息

PA1-1063

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

Assay-dependent

查看4篇已发表文章 4篇已发表文章

亲和纯化 (AP)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Bovine, Mouse, Rat

已发表种属

Bovine, C. elegans, Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues S(475) D K T P E E L F H P L G A D S Q V(492) of rat GLUT1.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2190931

产品详细信息

PA1-1063 detects GLUT1 in rat, mouse and bovine samples.

PA1-1063 has been successfully used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects a
~42 kDa protein representing GLUT1 in rat, mouse and bovine brain samples.

The PA1-1063 immunogen is a synthetic peptide corresponding to residues S(475) D K T P E E L F H P L G A D S Q V(492) of rat GLUT1. This sequence is conserved across many species including mouse, bovine, human, porcine and ovine. This peptide (Cat. # PEP-289) is available for use in neutralization and control experiments.

靶标信息

Glucose transporter 1 (GLUT1), encoded by the SLC2A1 gene, is a facilitative glucose transporter that plays a pivotal role in the uptake of glucose across cell membranes, particularly in tissues with high-energy demands such as the brain, erythrocytes, and endothelial cells of the blood-brain barrier. GLUT1 is ubiquitously expressed and functions through a passive diffusion mechanism, allowing glucose to move down its concentration gradient. Its involvement in maintaining glucose homeostasis is crucial for cellular metabolism and energy production. Mutations in SLC2A1 can lead to GLUT1 deficiency syndrome, characterized by seizures, developmental delay, and movement disorders due to impaired glucose transport into the brain. GLUT1 also plays a significant role in cancer biology, where its overexpression is commonly observed in various tumors, facilitating the enhanced glucose uptake required for rapid tumor cell proliferation. This characteristic makes GLUT1 a potential target for cancer diagnostics and therapeutics. Additionally, GLUT1's regulation is influenced by factors such as hypoxia, insulin, and cellular stress, highlighting its adaptive role in different physiological and pathological states.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: glucose transporter glut1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; GT1; MGC141895; MGC141896; solute carrier family 2 (facilitated glucose transporter), member 1; Solute carrier family 2 a 1 (facilitated glucose transporter) brain; Solute carrier family 2, facilitated glucose transporter member 1; solute carrier family 2, member 1

查看更多收起

基因别名: Glut-1; GLUT1; GLUTB; GTG1; Gtg3; RATGTG1; SLC2A1

查看更多收起

UniProt ID: (Bovine) P27674, (Mouse) P17809, (Rat) P11167

查看更多收起

Entrez Gene ID: (Bovine) 282356, (Mouse) 20525, (Rat) 24778

查看更多收起

功能