Invitrogen

GNAS (R201C Mutant) Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
GNAS (R201C Mutant) Polyclonal Antibody

产品信息

PA5-119556

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:5,000
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Carrier-protein conjugated synthetic peptide surrounding mutant R201C of mouse GNAS. The exact sequence is proprietary.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.96 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 1% BSA, 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2913129

产品详细信息

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

靶标信息

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2015]

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 5530400H20Rik; A930027G11Rik; Adenylate cyclase-stimulating G alpha protein; alpha stimulating) complex locus; Alternative gene product encoded by XL-exon; C130027O20Rik; Extra large alphas protein; G protein subunit alpha S; Galphas; GNAS (guanine nucleotide binding protein; Gnas1; Gnasxl; GPSA; Gs alpha subunit; Gs-alpha; Gsa; GSP; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Nesp; NESP55; Nespl; neuroendocrine secretory protein; Neuroendocrine secretory protein 55; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; POH; Protein ALEX; SCG6; secretogranin VI; stimulatory G-protein alpha subunit; XLalphas

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基因别名: 5530400H20Rik; A930027G11Rik; AHO; C130027O20Rik; C20orf45; Galphas; GNAS; GNAS1; Gnasxl; GPSA; GSA; GSP; MNCb-5546; NESP; Nespl; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; POH; SCG6; SgVI

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UniProt ID: (Human) P84996, (Mouse) Q6R0H6

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Entrez Gene ID: (Human) 2778, (Mouse) 14683

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功能
GTPase activity signal transducer activity insulin-like growth factor receptor binding protein binding GTP binding G-protein beta/gamma-subunit complex binding beta-2 adrenergic receptor binding D1 dopamine receptor binding mu-type opioid receptor binding ionotropic glutamate receptor binding metal ion binding corticotropin-releasing hormone receptor 1 binding nucleotide binding G-protein alpha-subunit binding guanyl nucleotide binding protein domain specific binding G-protein beta-subunit binding alpha-tubulin binding heterotrimeric G-protein
参与通路
tissue homeostasis endochondral ossification energy reserve metabolic process DNA methylation adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway sensory perception of chemical stimulus embryonic hindlimb morphogenesis multicellular organism growth post-embryonic body morphogenesis response to drug positive regulation of osteoblast differentiation positive regulation of osteoclast differentiation developmental growth embryonic cranial skeleton morphogenesis cognition cartilage development bone development hair follicle placode formation platelet aggregation genetic imprinting regulation of parathyroid hormone secretion skeletal system development positive regulation of protein phosphorylation regulation of transcription from RNA polymerase II promoter signal transduction G-protein coupled receptor signaling pathway post-embryonic development regulation of signal transduction positive regulation of sodium ion transport positive regulation of cAMP biosynthetic process negative regulation of renal sodium excretion negative regulation of multicellular organism growth positive regulation of GTPase activity skin development positive regulation of cAMP-mediated signaling negative regulation of blood pressure calcium ion homeostasis response to parathyroid hormone cellular response to prostaglandin E stimulus cellular response to catecholamine stimulus adenylate cyclase-activating adrenergic receptor signaling pathway
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