Invitrogen

GNB1 Polyclonal Antibody

查看其他5个GNB1抗体

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

PA5-30046

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:10,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:1,000
-

免疫组化（冰冻） (IHC (F))

Assay-dependent
-

免疫细胞化学 (ICC/IF)

1:100-1:1,000
-

免疫沉淀 (IP)

1:100-1:500
-

Proximity Ligation Assay (PLA) (PLA)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of human GNB1. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.32 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2547520

产品详细信息

Recommended positive controls: Jurkat, Raji, NCI-H929, Mouse brain.

Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (96%), Dog (100%), Chicken (97%), Rhesus Monkey (100%), Bovine (100%), Guinea pig (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain. The process of converting light into an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentration causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin activity is believed to be shut off by phosphorylation followed by binding of the soluble protein, arrestin. Transducin, once activated by rhodopsin, promotes the hydrolysis of cGMP by PDE. The subunit composition of transducin differs between different photoreceptor cells. Rod transducin consists of rod transducin alpha (Tr alpha), T beta, and T gamma. Cone transducin is composed of cone transducin alpha (Tc alpha), T beta and T gamma. Differential transducin subunit composition of transducin is believed to be responsible for the different light sensitivities between photoreceptive cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: beta subunit, signal-transducing proteins GS/GI; gbb1; guanine nucleotide binding protein (G protein), beta 1; guanine nucleotide binding protein (G protein), beta polypeptide 1; guanine nucleotide binding protein, beta 1; Guanine nucleotide-binding protein beta 1; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; guanine nucleotide-binding protein, beta-1 subunit; T beta; testicular tissue protein Li 72; Transducin beta chain 1

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基因别名: AA409223; C77571; Gnb-1; GNB1; MRD42

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UniProt ID: (Human) P62873, (Mouse) P62874, (Rat) P54311

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Entrez Gene ID: (Human) 2782, (Mouse) 14688, (Rat) 24400

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