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Agrisera
GORK/Potassium channel GORK Polyclonal Antibody
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产品信息
AS14-2795
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated peptide derived from Arabidopsis thaliana GORK protein.
偶联物
形式
Lyophilized
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
GORK encodes a plant Shaker-type, voltage-gated K+ channel that localizes predominantly to the plasma membrane of guard cells (and is also detected in peripheral puncta consistent with membrane microdomain clustering), where it provides the major outward-rectifying K+ conductance enabling K+ efflux during stomatal closure. The channel is built as a tetramer of pore-forming subunits; each subunit contains an N-terminal cytosolic region, six transmembrane helices (S1-S6) with a canonical re-entrant pore loop between S5 and S6 that confers high K+ selectivity, and a cytosolic C-terminal regulatory region. Recent structural work shows that the C terminus includes a C-linker coupled to a cyclic nucleotide-binding homology domain (CNBHD) and an ankyrin-repeat domain, with conformational rearrangements across this cytosolic module proposed to tune gating. Functionally, GORK mediates depolarization-activated, outwardly rectifying K+ currents and exhibits K+-dependent gating, properties that help ensure net K+ release when the electrochemical driving force favors efflux; loss-of-function or dominant-negative interference suppresses guard-cell outward K+ currents and perturbs stomatal movement and transpiration control.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AT5G37500; gated outwardly-rectifying K+ channel; MPA22.4; MPA22_4
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