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Invitrogen
GPAM Polyclonal Antibody
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GPAM Antibody (PA5-93092) in WB
Western blot analysis of GPAM in extracts of various cell lines. Samples were incubated with GPAM Polyclonal antibody (Product # PA5-93092) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-93092
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.66 mg/mL
规格
166 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LNKRGLGGPT STPPNLISQE QLVRKAASLC YLLSNEGTIS LPCQTFYQVC HETVGKFIQY GILTVAEHDD QEDISPSLAE QQWDKKLPEP LSWRSDEEDE DSDFGEEQRD CYLKVSQSKE HQQFITFLQR LLGPLLEAYS SAAIFVHNFS GPVPEPEYLQ KLHKYLITRT ERNVAVYAES ATYCLVKNAV KMFKDIGVFK ETKQKRVSVL ELSSTFLPQC NRQKLLEYIL SFVVL; Positive Samples: Mouse heart, Mouse lung, Rat brain; Cellular Location: Mitochondrion outer membrane, Multi-pass membrane protein
靶标信息
Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Glycerol-3-phosphate acyltransferase 1, mitochondrial; GPAT; GPAT-1; P90; RP11-426E5.2
基因别名: Gpam; GPAT; GPAT1
UniProt ID: (Mouse) Q61586, (Rat) P97564
Entrez Gene ID: (Mouse) 14732, (Rat) 29653
lipid metabolic process
fatty acid metabolic process
acyl-CoA metabolic process
triglyceride metabolic process
glycerophospholipid metabolic process
metabolic process
phospholipid biosynthetic process
response to glucose
positive regulation of triglyceride biosynthetic process
response to activity
triglyceride biosynthetic process
cellular response to insulin stimulus
positive regulation of multicellular organism growth
positive regulation of activated T cell proliferation
cellular lipid metabolic process
regulation of cytokine secretion
defense response to virus
fatty acid homeostasis
phospholipid homeostasis
negative regulation of activation-induced cell death of T cells
interleukin-2 secretion
response to fructose
CDP-diacylglycerol biosynthetic process
response to nutrient levels
response to cadmium ion
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