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Neuronal membrane glycoprotein M6-a is a protein that in humans is encoded by the GPM6A gene. Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: M6a; Neuronal membrane glycoprotein M6-a
基因别名: Gpm6; Gpm6a; M6A
UniProt ID: (Mouse) P35802, (Rat) Q812E9
Entrez Gene ID: (Mouse) 234267, (Rat) 306439