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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR125 (G protein-coupled receptor 125), also known as PGR21 or TEM5L, is a 1,321 amino acid multi-pass membrane protein belonging to the G-protein coupled receptor 2 family and the LN-TM7 subfamily. Considered a novel orphan adhesion-type G-protein-coupled receptor, GPR125 has five leucine rich repeats (LRR), an immunoglobulin (Ig) domain and a GPS domain. GPR125 may play a functional role in choroidal and hippocampal response to brain injury. It is also suggested that GPR125 may be a marker for spermatogonial stem cells. Four isoforms of GPR125 exists due to alternative splicing events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Adhesion G protein-coupled receptor A3; G protein-coupled receptor 125; G-protein coupled receptor 125; probable G-protein coupled receptor 125
基因别名: 3830613O22Rik; ADGRA3; AU044632; GPR125; PGR21; Tem5-like; TEM5L; UNQ556/PRO1113
UniProt ID: (Human) Q8IWK6, (Mouse) Q7TT36
Entrez Gene ID: (Human) 166647, (Mouse) 70693, (Rat) 305408