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Invitrogen
GPR160 Polyclonal Antibody
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产品信息
PA5-32806
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human GPR160.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (95%); Marmoset (85%); Rabbit (80%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
靶标信息
GPR160, part of the Class A family of G protein-coupled receptors (GPCRs), is prominently expressed in mouse embryonic stem cells and has been associated with various human solid tumors, particularly prostate cancer. The gene's expression contributes to the self-renewal and pluripotency of stem cells by participating in critical signaling pathways, including the JAK/STAT pathway, which is crucial for maintaining the stem cell cycle. High levels of GPR160 expression are observed in prostate cancer, though its role in disease progression is independent of the CARTp-mediated signaling pathway. Investigations into GPR160 have revealed its potential as a biomarker for prostate cancer. Additionally, it regulates mycobacteria entry into macrophages, implicating its functionality in immune responses. The gene's mechanisms of action, especially within cancer contexts, are subjects of ongoing research aimed at understanding its precise contributions to cellular proliferation and disease phenotypes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G-protein coupled receptor GPCR1; hGPCR1; Probable G-protein coupled receptor 160; putative G protein-coupled receptor
基因别名: GPCR1; GPCR150; GPR160
UniProt ID: (Human) Q9UJ42
Entrez Gene ID: (Human) 26996
