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Alomone Labs, LTD
GPR65 (TDAG8) (extracellular) Polyclonal Antibody, FITC
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GPR65 (TDAG8) (extracellular) Antibody (AGR-043-F-50UL) in Flow
Cell surface detection of GPR65 in live intact human Jurkat T-cell leukemia cells: - (black line) cells. (red) Cells + rabbit IgG isotype control-FITC. (green) Cells + Anti-GPR65 (TDAG8) (extracellular)-FITC Antibody (#AGR-043-F), (5 µg).
产品信息
AGR-043-F-50UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)DYTWNKDNWTFSP, corresponding to amino acid residues 72-84 of human GPR65, 1st extracellular loop
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
GPR65 also known as TDAG8 is a transmembrane protein belonging to the G protein coupled receptor super family with 337-amino acid and 90% similarity and 81% identity in the 7 transmembrane domains of its mouse homolog. It has 3 potential N-linked glycosylation sites and is expressed predominantly in lymphoid organs and cancer tissues with increased expression during activation-induced death of T-cell hybridomas. Two major transcripts of 4.5 kb and 1.8 kb are found in peripheral blood leukocytes and functions as a novel proton-sensing receptor. It couples to adenylyl cyclase and psychosine and is also actively involved in the establishment of immunological autotolerance. GPR65 has a role in cellular transformation by RhoA activation and actin rearrangement under conditions accompanying tissue acidosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G-protein coupled receptor 25; G-protein coupled receptor 65; Psychosine receptor; T cell death associated protein 8; T-cell death-associated gene 8 protein
基因别名: Dig1; Gpcr25; GPR65; hTDAG8; TDAG8
UniProt ID: (Human) Q8IYL9, (Mouse) Q61038
Entrez Gene ID: (Human) 8477, (Rat) 299242, (Mouse) 14744
apoptotic process
immune response
G-protein coupled receptor signaling pathway
multicellular organism development
response to acidic pH
positive regulation of cAMP biosynthetic process
actin cytoskeleton reorganization
positive regulation of stress fiber assembly
activation of GTPase activity
signal transduction
