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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLJ42530; GTPase regulator associated with focal adhesion kinase pp125(FAK); oligophrenin-1-like protein; rho-type GTPase-activating protein 26; unnamed protein product
基因别名: 1810044B20Rik; 2610010G17Rik; 4933432P15Rik; GRAF; GRAF1; mKIAA0621; OPHN1L; OPHN1L1
UniProt ID: (Human) Q9UNA1, (Mouse) Q6ZQ82
Entrez Gene ID: (Human) 23092, (Rat) 307459, (Mouse) 71302