Search Thermo Fisher Scientific
图: 1 / 1
Catalyzes the irreversible reduction of the cytotoxic compound methylglyoxal (MG, 2-oxopropanal) to (S)-lactaldehyde as an alternative to detoxification of MG by glyoxalase I GLO1. MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation. Also catalyzes the reduction of 3-methylbutanal to 3-methylbutanol. Acts as a suppressor of 3-methylbutanol-induced filamentation by modulating the levels of 3-methylbutanal, the signal to which cells respond by filamentation. Also involved in ergosterol metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 3-methylbutanal reductase; Genes de respuesta a estres protein 2; Isovaleraldehyde reductase; NADPH-dependent methylglyoxal reductase; NADPH-dependent methylglyoxal reductase GRE2
基因别名: GRE2; YOL151W
UniProt ID: (Baker's yeast) Q12068
Entrez Gene ID: (Baker's yeast) 854014
分子生物学功能: dehydratase