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Invitrogen
GREM1 Recombinant Human Monoclonal Antibody (1D9)
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GREM1 Antibody (MA5-60784) in IHC (P)
Immunohistochemistry analysis of GREM1 in paraffin-embedded human gastric cancer. Samples were incubated with GREM1 Recombinant Monoclonal antibody (Product # MA5-60784) using a dilution of 1:100 followed by detection with Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Sect... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-60784
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1D9
抗原
Recombinant Human GREM1 protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.8 mg/mL
规格
180 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BMP antagonist; BMP antagonist; Dan family member; cell proliferation-inducing gene 2 protein; colorectal adenoma and carcinoma 1; cysteine knot superfamily 1, BMP antagonist 1; DAN domain family member 2; down-regulated in Mos-transformed cells protein; gremlin; gremlin 1, cysteine knot superfamily, homolog; gremlin 1-like protein; hereditary mixed polyposis syndrome; increased in high glucose-2; PIG2; unnamed protein product
基因别名: C15DUPq; CKTSF1B1; CRAC1; CRCS4; DAND2; DRM; DUP15q; GREMLIN; HMPS; HMPS1; IHG-2; MPSH; PIG2
UniProt ID: (Human) O60565
Entrez Gene ID: (Human) 26585
cell morphogenesis
cell migration involved in sprouting angiogenesis
positive regulation of receptor internalization
mesenchymal to epithelial transition involved in metanephros morphogenesis
signal transduction
positive regulation of cell proliferation
regulation of epithelial to mesenchymal transition
collagen fibril organization
negative regulation of bone mineralization
negative regulation of BMP signaling pathway
negative regulation of chondrocyte differentiation
regulation of stress-activated MAPK cascade
negative regulation of osteoblast proliferation
negative regulation of apoptotic process
endothelial cell migration
negative regulation of osteoblast differentiation
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of bone remodeling
determination of dorsal identity
regulation of focal adhesion assembly
cardiac muscle cell differentiation
limb development
cardiac muscle cell myoblast differentiation
negative regulation of SMAD protein import into nucleus
ureteric bud formation
signal transduction by p53 class mediator
negative regulation of monocyte chemotaxis
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of canonical Wnt signaling pathway
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of osteoclast proliferation
negative regulation of bone trabecula formation
negative regulation of bone mineralization involved in bone maturation
positive regulation of vascular endothelial growth factor signaling pathway
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