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Abnova
GRM8 Monoclonal Antibody (4A7)
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产品信息
H00002918-M06
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4A7
抗原
GRM8 (NP_000836, 486 a.a. approximately 575 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: KVIGHWTNQL HLKVEDMQWA HREHTHPASV CSLPCKPGER KKTVKGVPCC WHCERCEGYN YQVDELSCEL CPLDQRPNMN RTGCQLIPII
靶标信息
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ41058; glutamate receptor; glutamate receptor, metabotropic 8; M mGlu8; Metabotropic glutamate receptor 8; MGC126724; mGluR8
基因别名: GLUR8; GPRC1H; GRM8; mGlu8; MGLUR8
UniProt ID: (Human) O00222
Entrez Gene ID: (Human) 2918
