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NeoBiotechnologies
GRP94/HSP90B1 (Endoplasmic Reticulum Marker) Monoclonal Antibody (9G10.F8.2)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
7184-RTM1-P0
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Dog,
Chicken,
Horse,
Guinea pig,
Hamster,
Human,
Mouse,
Non-human primate,
Sheep,
Pig,
Rabbit,
Rat,
Xenopus
宿主/亚型
Rat
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
9G10.F8.2
抗原
Purified glucose regulated protein 94 (grp94) from chicken oviducts
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
200 µg/mL
规格
20 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
GRP94 is a 803 amino acid protein belonging to the heat shock protein 90 family. It acts as a molecular chaperone that functions in the processing and transport of secreted proteins. GRP94 and its N-terminal fragment stimulates CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC). It plays a central role in innate as well as acquired immunity, maturation and chemotaxis of dendritic cells, Ab production, cross-priming, as a potential marker in breast cancer and is a peptide acceptor in endoplasmic reticulum and an accessory to peptide loading of MHC class I molecules. Expression of GRP94 suppressed A23187-induced apoptosis and stabilized calcium homeostasis. GRP94 is expressed in melanoma or liver metastases of colon carcinoma cells, human gastric carcinoma BGC-823 cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 108K heat shock protein; 108K HSP; 94 kDa glucose-regulated protein; 98 kDa protein kinase; endoplasmic reticulum resident protein 99; endoplasmic reticulum transmembrane protein precursor; Endoplasmin; endoplasmin-like protein; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; glucose-regulated protein; glucose-regulated protein GRP94; gp96 homolog; GRP-94; GRP94; heat shock 108 kDa protein; heat shock protein 108; heat shock protein 108.; heat shock protein 90 kDa beta member 1; heat shock protein 90, beta (Grp94), member 1; heat shock protein 90, beta, member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; heat shock protein 90kDa beta, member 1; heat shock protein family C member 4; heat shock protein gp96; HSP 108; hsp108; HSP90 beta; polymorphic tumor rejection antigen 1; polymorphic tumor rejection antigen precursor; PPK 98; stress-inducible tumor rejection antigen gp96; transferrin-binding protein; transforming growth factor alpha regulated gene 2; tumor rejection antigen; tumor rejection antigen (gp96) 1; tumor rejection antigen 1; tumor rejection antigen gp96; unnamed protein product
基因别名: ECGP; endoplasmin; ERp99; GP96; GRP94; HEL-S-125m; HEL35; hsp108; hsp90b1; ppk98; TA-3; Targ2; Tra-1; TRA1; XELAEV_18017384mg
RNA binding
ATP binding
protein phosphatase binding
low-density lipoprotein particle receptor binding
unfolded protein binding
protein phosphatase inhibitor activity
calcium ion binding
protein binding
ATPase activity
AP-3 adaptor complex binding
protein binding involved in protein folding
ATP-dependent protein folding chaperone
Hsp90 family chaperone
response to hypoxia
ER-associated ubiquitin-dependent protein catabolic process
retrograde protein transport, ER to cytosol
actin rod assembly
negative regulation of apoptotic process
regulation of phosphoprotein phosphatase activity
cellular response to ATP
protein folding
intracellular sequestering of iron ion
response to hormone
protein transport
positive regulation of Wnt signaling pathway
positive regulation of toll-like receptor signaling pathway
protein folding in endoplasmic reticulum
response to endoplasmic reticulum stress
ERAD pathway
cellular response to manganese ion
protein localization to plasma membrane
insulin processing
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