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Invitrogen
GSDME (cleaved N terminal) Recombinant Rabbit Monoclonal Antibody (2F2O10)
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产品信息
MA575667
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2F2O10
抗原
Synthetic peptide. This information is considered to be commercially sensitive.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.24 mg/mL
规格
124 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 0.05% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The cleaved N-terminal fragment of GSDME is the active pore-forming domain generated after caspase-mediated cleavage. This fragment oligomerizes in the plasma membrane to form pores, leading to cell swelling, membrane rupture, release of inflammatory mediators, and execution of pyroptotic cell death.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DFNA5, deafness associated tumor suppressor; expression inversely correlated with estrogen receptor expression in breast cancer; inversely correlated with estrogen receptor expression 1; non-syndromic hearing impairment protein 5; nonsyndromic hearing impairment protein; unnamed protein product
基因别名: DFNA5; ICERE-1
UniProt ID: (Human) O60443
Entrez Gene ID: (Human) 1687
positive regulation of immune response to tumor cell
sensory perception of sound
negative regulation of cell proliferation
programmed cell death
positive regulation of MAPK cascade
transmembrane transport
pyroptosis
cellular response to tumor necrosis factor
cellular response to virus
granzyme-mediated programmed cell death signaling pathway
pyroptotic cell death
positive regulation of intrinsic apoptotic signaling pathway
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