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The antibody detects endogenous levels of total TFIIIA / GTF3A protein.
The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein.
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蛋白别名: TF3A; TFIIIA; Transcription factor IIIA
基因别名: AP2; GTF3A; TFIIIA
UniProt ID: (Human) Q92664
Entrez Gene ID: (Human) 2971