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Fabgennix
GTP cyclohydrolase 1 Polyclonal Antibody
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GTP cyclohydrolase 1 Antibody (GTPCH1-112AP) in IHC
Mouse Spleen- GTP cyclohydrolase 1 Primary Antibody: GTPCH1-112AP; 1:100 dilution in IHC Blocking Buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification on Leica DM4000B microscope. FFPE section. Rabbit # 647.Pb3.AP.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
GTPCH1-112AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 25-75 on mouse GTPCHI protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GTP cyclohydrase I; GTP cyclohydrolase I; GTP-CH-I; unnamed protein product
基因别名: Gch; GTP-CH; GTP-CH-I; GTPCH; GTPCH-1
UniProt ID: (Rat) P22288, (Mouse) Q05915
Entrez Gene ID: (Rat) 29244, (Mouse) 14528
tetrahydrobiopterin biosynthetic process
regulation of blood pressure
positive regulation of heart rate
negative regulation of cardiac muscle cell apoptotic process
regulation of lung blood pressure
positive regulation of telomere maintenance via telomerase
response to lipopolysaccharide
response to interferon-gamma
response to tumor necrosis factor
vasodilation
dopamine biosynthetic process
pteridine-containing compound metabolic process
pteridine-containing compound biosynthetic process
positive regulation of neuron apoptotic process
negative regulation of blood pressure
tetrahydrobiopterin metabolic process
tetrahydrofolate biosynthetic process
response to pain
neuromuscular process controlling posture
positive regulation of nitric-oxide synthase activity
dihydrobiopterin metabolic process
protein-containing complex assembly
regulation of removal of superoxide radicals
negative regulation of cellular senescence
cellular response to lipopolysaccharide
regulation of serotonin biosynthetic process
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