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Invitrogen
Ganglioside GD2 (Donitabart Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA562575
应用
建议稀释比
已发表文章
产品规格
种属反应
Chemical
宿主/亚型
Human
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA562575 is a chimeric antibody. The variable regions from one species have been grafted to the backbone of the other species.
靶标信息
Ganglioside GD2 is a disialoganglioside (glycosphingolipid) expressed on the outer surface of the plasma membrane. It is highly expressed in tumors of neuroectodermal origin, including neuroblastoma, melanoma, osteosarcoma, and small cell lung cancer, while showing limited distribution in normal tissues, primarily in peripheral nerves and the central nervous system. GD2 plays roles in cell adhesion, migration, and signal transduction. Because of its high tumor expression and restricted normal tissue distribution, GD2 is an established target for antibody-based immunotherapies, particularly in high-risk neuroblastoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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