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Invitrogen
Gatralimab Chimeric Recombinant Human Monoclonal Antibody
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Gatralimab Chimeric Antibody (MA5-42273) in SDS-PAGE
SDS-PAGE analysis of the recombinant Human CD52 protein expressed in CHO cells using a Gatralimab biosimilar monoclonal antibody (Product # MA5-42273). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
产品信息
MA5-42273
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human CD52
偶联物
形式
Liquid
浓度
4.47 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.5
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
Gatralimab is a biosimilar that targets CD52. Human CD52, also known as Cambridge pathology antigen 1 (CAMPATH-1), is a glycoprotein found in the male reproductive tract and immune cells. It is abundantly expressed on the surface of nearly all human peripheral blood lymphocytes. The CD52 antigen is Gpi-anchored membrane receptor that consists of a small 12 amino acid peptide attached to a large N-linked carbohydrate group. CD52 is a potent target for inducing cytolysis of mature lymphocytes. Alemtuzumab, a humanized monoclonal antibody targeting CD52, is used as an immunomodulatory drug for the treatment of chronic lymphocytic leukemia, T cell lymphomas, multiple sclerosis, and other diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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