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Invitrogen
Glibenclamide Recombinant Mouse Monoclonal Antibody (2H11)
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Glibenclamide Antibody (MA566471) in SDS-PAGE
SDS-PAGE characterization of Glibenclamide under reducing conditions. Lane M: Protein marker (kDa); Lane GBC: Purified Glibenclamide Recombinant Monoclonal (Product # MA566471). Glibenclamide showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-634.
产品信息
MA566471
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2H11
抗原
Conjugate of GBC hapten and KLH.
偶联物
形式
Liquid
浓度
1.67 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Glibenclamide, also known as glyburide, is a second-generation sulfonylurea used primarily in the management of type 2 diabetes mellitus. It functions by stimulating insulin secretion through the inhibition of ATP-sensitive potassium channels on pancreatic beta cells, leading to increased intracellular potassium and calcium ion concentrations. The gene encoding for the ATP-sensitive potassium channel is located on chromosome 11, and its structure is crucial for the drug's mechanism of action. Glibenclamide is often combined with metformin hydrochloride to enhance glycemic control by addressing complementary mechanisms. Various formulations of glibenclamide exist, including modified-release versions, which aim to improve bioavailability and control drug release. These formulations are evaluated for bioequivalence and pharmacodynamics to ensure consistent therapeutic effects.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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