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Alomone Labs, LTD
Glucagon Receptor (extracellular) Polyclonal Antibody
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Glucagon Receptor (extracellular) Antibody (AGR-024-200UL) in IHC (F)
Expression of Glucagon receptor in mouse hypothalamus - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-Glucagon Receptor (extracellular) Antibody (#AGR-024), (1:200), followed by goat- Anti-rabbit-AlexaFluor-488 secondary Antibody . GCGR staining (green) in mouse hypothalamus is detected in neurons (arrows) from the 3rdventricle wall outlining the paraventricular nucle... View More
产品信息
AGR-024-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KTRYSQKIGDDLS, corresponding to amino acid residues 200-212 of rat GCGR, 1st extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Glucagon receptors are G-protein coupled receptors for glucagon and play a central role in the regulation of blood glucose levels and glucose homeostatsis. It regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Glucagon receptors also play an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G-proteins) and modulates the activity of down-stream effectors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GL-R; Glucagon receptor; glucagon receptor perhaps same as Niddm3
基因别名: GCGR; GGR; GL-R; GR
UniProt ID: (Human) P47871, (Mouse) Q61606, (Rat) P30082
Entrez Gene ID: (Human) 2642, (Mouse) 14527, (Rat) 24953
generation of precursor metabolites and energy
exocytosis
cell surface receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
response to nutrient
regulation of blood pressure
hormone-mediated signaling pathway
glucose homeostasis
response to starvation
positive regulation of GTPase activity
regulation of glycogen metabolic process
cellular response to glucagon stimulus
signal transduction
G-protein coupled receptor signaling pathway
