Invitrogen

Growth Hormone Receptor Recombinant Rabbit Monoclonal Antibody (JU01-34)

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Growth Hormone Receptor Recombinant Rabbit Monoclonal Antibody (JU01-34)

产品信息

MA5-32831

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500
-

免疫组化（石蜡） (IHC (P))

1:50-1:1,000
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-

流式细胞分析 (Flow)

1:50-1:100
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

JU01-34

抗原

Synthetic peptide within Human Growth hormone receptor aa 537-586
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2810107

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

Growth hormone receptor (GHR) is a gene located on chromosome 5p13.1, encoding a transmembrane receptor that plays a critical role in mediating the effects of growth hormone, which is crucial for growth, metabolism, and tissue development. GHR is expressed in various tissues, including the liver, muscle, and adipose tissue, and facilitates the growth hormone signaling pathway by binding to growth hormone, leading to receptor dimerization and activation of intracellular signaling cascades such as the JAK2-STAT5 pathway. This signaling promotes growth and anabolic processes, influencing body composition, insulin sensitivity, and lipid metabolism. Mutations or alterations in the GHR gene can lead to growth disorders like Laron syndrome, characterized by insensitivity to growth hormone. Understanding GHR's structure and function is pivotal for developing therapeutic strategies for growth deficiencies and metabolic syndromes, as modifying GHR signaling pathways can offer potential interventions in related conditions.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: GH receptor; growth hormone binding protein; Growth hormone receptor; Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein); growth hormone receptor precursor splice variant D56; growth hormone receptor variant d5-6; growth hormone receptor/binding protein; MGC124963; MGC156665; serum binding protein; Somatotropin receptor

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基因别名: GHBP; GHIP; GHR; GHR/BP

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UniProt ID: (Human) P10912, (Rat) P16310, (Mouse) P16882

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Entrez Gene ID: (Human) 2690, (Rat) 25235, (Mouse) 14600

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功能
cytokine receptor activity protein binding peptide hormone binding protein kinase binding protein homodimerization activity proline-rich region binding growth hormone receptor activity growth factor binding protein phosphatase binding SH2 domain binding transmembrane signal receptor
参与通路
activation of MAPK activity allantoin metabolic process citrate metabolic process 2-oxoglutarate metabolic process succinate metabolic process oxaloacetate metabolic process isoleucine metabolic process valine metabolic process creatine metabolic process fatty acid metabolic process endocytosis JAK-STAT cascade cytokine-mediated signaling pathway taurine metabolic process cellular response to hormone stimulus regulation of multicellular organism growth positive regulation of multicellular organism growth positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of tyrosine phosphorylation of Stat5 protein activation of JAK2 kinase activity multicellular organism metabolic process creatinine metabolic process insulin-like growth factor receptor signaling pathway positive regulation of peptidyl-tyrosine phosphorylation growth hormone receptor signaling pathway JAK-STAT cascade involved in growth hormone signaling pathway response to hormone hormone-mediated signaling pathway receptor internalization response to food response to estradiol cellular response to insulin stimulus response to cytokine activation of Janus kinase activity response to morphine response to peptide hormone positive regulation of cell differentiation positive regulation of JAK-STAT cascade response to cycloheximide response to glucocorticoid cartilage development involved in endochondral bone morphogenesis response to interleukin-1 negative regulation of neuron death
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