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Agrisera
Grx5/Monothiol glutaredoxin-S5 Polyclonal Antibody
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产品信息
AS15-3108
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
His-tagged, full length recombinant Grx5 of Arabidopsis thaliana.
偶联物
形式
Lyophilized
保存液
whole serum
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
GLRX5 encodes a conserved mitochondrial glutaredoxin that is synthesized as a precursor bearing an N-terminal mitochondrial targeting sequence and is imported to the mitochondrial matrix, where it functions in iron-sulfur (Fe-S) cluster biogenesis and cellular iron homeostasis. The protein is a small monothiol glutaredoxin family member with a single glutaredoxin-like domain and a characteristic CGFS active-site motif that supports coordination/handling of a [2Fe-2S] cluster, consistent with a role as an Fe-S cluster transfer/assembly factor within the mitochondrial ISC machinery. Functionally, GLRX5 is required for maturation of mitochondrial Fe-S proteins and for maintaining proper distribution of iron between mitochondrial and cytosolic pools; loss of GLRX5 activity impairs Fe-S cluster formation, perturbs iron regulation, and in erythroid cells can secondarily compromise heme biosynthesis by disrupting Fe-S-dependent steps and iron-responsive regulatory pathways, causing autosomal recessive pyridoxine-refractory sideroblastic anemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C14orf87; FLB4739; GRX5; PR01238; PRO1238; PRSA; SIDBA3; SPAHGC
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